ⓘ PRKAG3

                                     

ⓘ PRKAG3

The protein encoded by this gene is a regulatory subunit of the AMP-activated protein kinase AMPK. AMPK is a heterotrimer consisting of an alpha catalytic subunit, and non-catalytic beta and gamma subunits. AMPK is an important energy-sensing enzyme that monitors cellular energy status. In response to cellular metabolic stresses, AMPK is activated, and thus phosphorylates and inactivates acetyl-CoA carboxylase ACC and beta-hydroxy beta-methylglutaryl-CoA reductase HMGCR, key enzymes involved in regulating de novo biosynthesis of fatty acid and cholesterol. This subunit is one of the gamma regulatory subunits of AMPK. It is dominantly expressed in skeletal muscle. Studies of the pig counterpart suggest that this subunit may play a key role in the regulation of energy metabolism in skeletal muscle.

                                     
  • protein kinase subunit gamma - 2 is an enzyme that in humans is encoded by the PRKAG 2 gene. AMP - activated protein kinase AMPK is a heterotrimeric protein composed
  • protein kinase subunit gamma - 1 is an enzyme that in humans is encoded by the PRKAG 1 gene. The protein encoded by this gene is a regulatory subunit of the AMP - activated
  • regulatory domain, has three isoforms: γ1, γ2, and γ 3 which are encoded from PRKAG 1, PRKAG 2, and PRKAG3 In human skeletal muscle, the preferred form is α2β2γ1
  • 1q21.1 duplication syndrome PRKAB2 has been shown to interact with PRKAG 2 and PRKAG 1. Research on the genes CHD1L and PRKAB2 within lymphoblast cells lead
  • Myosin light chain kinase 3 also known as MYLK 3 is an enzyme which in humans is encoded by the MYLK 3 gene. Phosphorylation of cardiac myosin heavy chains
  • kinase kinase 3 is an enzyme that in humans is encoded by the MAP 3 K 3 gene, which is located on the long arm of chromosome 17 17q23. 3 This gene product
  • levels, increased IgG 3 levels, and a number of atypical haematology parameters. PRKAB1 has been shown to interact with PRKAG 2 and PRKAG 1. The 5 - AMP - activated
  • MAP kinase - activated protein kinase 3 is an enzyme that in humans is encoded by the MAPKAPK 3 gene. This gene encodes a member of the Ser Thr protein kinase
  • Cell division protein kinase 3 is an enzyme that in humans is encoded by the CDK 3 gene. CDK 3 complements cdc28 mutants of Saccharomyces cerevisiae suggesting
  • Polo - like kinase 3 Drosophila also known as PLK 3 is an enzyme which in humans is encoded by the PLK 3 gene. Cytokine - inducible kinase is a putative