ⓘ MDFI

                                     

ⓘ MDFI

This protein is a transcription factor that negatively regulates other myogenic family proteins. Studies of the mouse homolog, I-mf, show that it interferes with myogenic factor function by masking nuclear localization signals and preventing DNA binding. Knockout mouse studies show defects in the formation of vertebrae and ribs that also involve cartilage formation in these structures.

                                     
  • humans is encoded by the RABL6 gene. RABL6 has been shown to interact with MDFI GRCh38: Ensembl release 89: ENSG00000196642 - Ensembl, May 2017 GRCm38:
  • transcript 1 of the CCDC120 gene. Usher Syndrome 1C Binding Protein 1, CYTH2, MDFI Centrosomal Protein 170kDa Pseudogene 1, and Keratin 15 have all been shown
  • variety of non - muscle cell types. Myogenin has been shown to interact with: MDFI POLR2C, Serum response factor Sp1 transcription factor, and TCF3. GRCh38:
  • been shown to interact with: EYA2, GPSM2, Interleukin 8 receptor, alpha, MDFI RGS5, and RIC8A. GRCh38: Ensembl release 89: ENSG00000114353 - Ensembl
  • KCTD17, ZNF655, BANP, SPERT, NFKBID, ZNF526, PCSK5, DVL3, AJUBA, PPP1R16B, MDFI DPH2, CDCA4, KRTAP3 - 3, BACH2, KCNF1, MAN1C1, RIMBP3, ZRANB1, ISY1, FKBP7
  • protein has binary interactions with NOTCH2NL, KRTAP5 - 9, KRTAP4 - 2, KRTAP10 - 8, MDFI and KRT40. Solute carrier family GRCh38: Ensembl release 89: ENSG00000183048
  • kinase 4, Cyclin - dependent kinase inhibitor 1C, EP300, HDAC1, ID1, ID2, MDFI MOS, Retinoblastoma protein, Retinoid X receptor alpha STAT3, and TCF3.