ⓘ STK39

                                     

ⓘ STK39

STE20/SPS1-related proline-alanine-rich protein kinase is an enzyme that in humans is encoded by the STK39 gene.

This gene encodes a serine / threonine kinase that function in the cellular stress response path. Kinases are activated in response to hypotonic stress, leading to phosphorylation of several cation-chloride-coupled cotransporters. The catalytically active kinase specifically activates the P38 map kinase pathway and its interaction with a p. 38 is reduced by cellular stress, suggesting that this kinase may serve as an intermediate in the response to cellular stress. Some studies suggest that this gene may be associated with high blood pressure.