ⓘ GFRA2 (gene)

                                     

ⓘ GFRA2 (gene)

The GFRA2 protein is a glycosylphosphatidylinositolGPI-linked cell surface receptor. It is part of the GDNF receptor family. Glial cell line-derived neurotrophic factor GDNF and neurturin NTN are two structurally related, potent neurotrophic factors that play key roles in the control of neuron survival and differentiation. They both bind the GFRA2 receptor. The receptor mediates activation of the RET tyrosine kinase receptor. This encoded protein acts preferentially as a receptor for NTN compared to its other family member, GDNF family receptor alpha 1. This gene is a candidate gene for RET-associated diseases.

                                     
  • receptor, is a protein that in humans is encoded by the GFRA 3 gene The protein encoded by this gene is a glycosylphosphatidylinositol GPI - linked cell surface
  • known as the GDNF receptor, is a protein that in humans is encoded by the GFRA 1 gene Glial cell line - derived neurotrophic factor GDNF and neurturin NTN
  • the persephin receptor, is a protein that in humans is encoded by the GFRA 4 gene GFRα GRCh38: Ensembl release 89: ENSG00000125861 - Ensembl, May 2017
  • RET gene 37 while two of the ten URA fetuses did 20 One of the URA fetuses had two RET mutations and one GDNF mutation. There were no GFRA 1 mutations