ⓘ Myoferlin

                                     

ⓘ Myoferlin

Myoferlin is a protein that in humans is encoded by the MYOF gene.

Mutations in dysferlin, proteins associated with the plasma membrane, can cause muscle weakness that affects proximal and distal muscles. The protein encoded by this gene is a membrane type, a second protein that is structurally similar to dysferlin. He is a member of the ferlin family and is associated with plasma and nuclear membranes. Myoferlin contains C2 domains that play an important role in calcium-mediated membrane fusion events, suggesting that it may be involved in membrane regeneration and repair. Myoferlin also contains the domain Fera. The domain Fehr was shown to interact with the membrane, suggesting that the domain Fehr in myoferlin may contribute myoferlins the mechanism of interaction of the membrane. Myoferlin is expressed redundantly in several types of cancer, especially triple-negative breast cancer. Overexpression of myoferlin is associated with proliferation, migration and invasion of cancer cells and suppression of gene myoferlins in triple-negative breast cancer can significantly reduce tumor growth and metastatic. Two transcripts encoding different isoforms have been found for this gene. Other possible variants have been discovered, but their full length nature has not been determined.