ⓘ Sirtuin 5

                                     

ⓘ Sirtuin 5

Sirtuin 5, also known as SIRT5 is a protein which in humans in encoded by the SIRT5 gene and in other species by the orthologous Sirt5 gene.

This gene encodes a member of the family sirtuin proteins, homologs to the yeast Sir2 protein. Family members are characterized by certain sirtuin primary domain and belong to class III in superfamily, and dependent on NAD as a cofactor in enzymatic activities. SIRT5 is one of the three sirtuins localize mainly in the mitochondria.

                                     
  • Sirtuins are a class of proteins that possess either mono - ADP - ribosyltransferase, or deacylase activity, including deacetylase, desuccinylase, demalonylase
  • Sirtuin - activating compounds STAC are chemical compounds having an effect on sirtuins a group of enzymes that use NAD to remove acetyl groups from
  • Sirtuin 1, also known as NAD - dependent deacetylase sirtuin - 1, is a protein that in humans is encoded by the SIRT1 gene. SIRT1 stands for sirtuin silent
  • NAD - dependent deacetylase sirtuin 2 is an enzyme that in humans is encoded by the SIRT2 gene. SIRT2 is an NAD nicotinamide adenine dinucleotide - dependent
  • Sirtuin 4, also known as SIRT4, is a protein which in humans is encoded by the SIRT4 gene. This gene encodes a member of the sirtuin family of proteins
  • Sirtuin 6 SIRT6 or Sirt6 is a stress responsive protein deacetylase and mono - ADP ribosyltransferase enzyme encoded by the SIRT6 gene. SIRT6 functions
  • endproducts inhibitory effects. It is also a sirtuin - activating compound, a chemical compound having an effect on sirtuins a group of enzymes that use NAD to
  • protein that belongs to the sirtuin family, a broadly conserved family of NAD - dependent protein deacetylases. PDB: 1S 5 P Zhao K, Chai X, Marmorstein
  • deacetylase HDAC families of enzymes, but not class III HDACs i.e., sirtuins However, there are recent reports of the interactions of this molecule
  • toxicity caused by decrease in PPARγ coactivator 1 - α PPARGC1A, PGC1α and sirtuin 1 SIRT1 Wilding JP, Gause - Nilsson I, Persson A September 2007 Tesaglitazar
  • Matthew LaPlante. While Sinclair was in Guarente s lab, he discovered that Sirtuin 1 called sir2 in yeast slows aging in yeast by reducing the accumulation
  • Sirtris Pharmaceuticals intended as a small - molecule activator of the sirtuin subtype SIRT1. The compound has been studied in animals, but safety and