ⓘ CORIN

                                     

ⓘ CORIN

Human corin, a polypeptide of 1042 amino acids, consists of an N-terminal cytoplasmic domain, a transmembrane domain and an extracellular region with two frizzled-like domains, eight LDL receptor-like domains, a scavenger receptor-like domain and a C-terminal trypsin-like serine protease domain. Corin is synthesized as a zymogen that is activated by PCSK6.

Corinne shows trypsin-like catalytic activity in favor of a basic residue at position P1.

Human Corin contains 19 sites of N-glycosylation. N-glycans contribute to the Corin expression on the cell surface and to protect Corinne from metalloproteinase-mediated shedding.