ⓘ TRIM22

                                     

ⓘ TRIM22

The protein encoded by this gene is a member of the tripartite motif TRIM family. The TRIM motif includes three zinc-binding domains, a RING, a B-box type 1 and a B-box type 2, and a coiled-coil region. This protein localizes to the cytoplasm and its expression is induced by interferon. TRIM22 is also a target gene of the tumor suppressor protein p53.

TRIM22 possesses E3 ubiquitin-ligase activity and is able ubiquitinate itself with the help of the E2 enzyme UbcH5B. In addition, TRIM22 is located in the nucleus and, therefore, can function as a ubiquitin E3 ligase nuclear.

                                     
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  • TRIM 7, TRIM 10 11 - 20: TRIM 11, TRIM 12, TRIM 15, TRIM 17, TRIM 20 21 - 30: TRIM 21, TRIM22 TRIM 26, TRIM 27, TRIM 30 31 - 40: TRIM 31, TRIM 34, TRIM 35, TRIM 38, TRIM 39
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