ⓘ ULBP2

                                     

ⓘ ULBP2

UL16 binding protein 2 is a cell surface glycoprotein encoded by ULBP2 gene located on the chromosome 6. ULBP2 is related to MHC class I molecules, but its gene maps outside the MHC locus. The domain structure of ULBP2 differs significantly from those of conventional MHC class I molecules. It does not contain the α3 domain and the transmembrane segment. ULBP2 is thus composed of only the α1α2 domain which is linked to the cell membrane by the GPI anchor. It functions as a stress-induced ligand for NKG2D receptor.

                                     
  • infection on ligands for the activating NKG 2 D receptor of NK cells: up - regulation of UL16 - binding protein ULBP 1 and ULBP2 is counteracted by the viral UL16 protein
  • UL16 binding protein 3 ULBP 3 is a cell surface glycoprotein encoded by ULBP 3 gene located on the chromosome 6. ULBP 3 is related to MHC class I molecules
  • human RAET1 ULBP genes, six encode functional proteins: RAET1E ULBP 4, RAET1G ULBP 5, RAET1H ULBP2 RAET1 ULBP 1, RAET1L ULBP 6, RAET1N ULBP 3. In mice, proteins
  • bind to NKG 2 D receptor can be divided into two families of MHC class I - related proteins: MICs MICA, MICB and ULBPs ULBP 1, ULBP2 ULBP 3, ULBP 4, RAET1G
  • with other CD94 NKG 2 family members, NKG 2 D binds MHC class I homologues MICA MHC class I polypeptide - related sequence A MICB and ULBP UL - 16 binding protein
  • James R. Jafferji, Insiya Trowsdale, John 2009 - 11 - 01 ULBP 6 RAET1L is an additional human NKG 2 D ligand European Journal of Immunology. 39 11 3207 3216
  • William A Rein - Weston, Annie Cosman, David 2003 - 05 - 23 ULBP 4 is a novel ligand for human NKG 2 D Biochemical and Biophysical Research Communications.
  • Human ULBP RAET1 Molecules with Transmembrane Regions Are Ligands for NKG 2 D The Journal of Immunology. 173 2 1078 1084. doi: 10.4049 jimmunol.173. 2 1078
  • evasion of NK cell responses. It binds to ligands ULBP 1, ULBP2 and MICB of NK cell activating receptor NKG 2 D, which prevents their surface expression. These