ⓘ PDE6A

                                     

ⓘ PDE6A

Rod cGMP-specific 3.5-cyclic phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE6A gene.

PDE6A encodes the cyclic cGMP specific phosphodiesterase 6A alpha subunit, expressed in cells of the retinal rod outer segment. On phosphodiesterase 6 holoenzyme is a heterotrimer composed of alpha -, beta-and two gamma-subunits.cGMP is an important regulator of plasma membrane current, and its dynamic concentration is established phosphodiesterase 6A cGMP hydrolysis and gunylate enzyme synthesis of cGMP. Mutations in PDE6A have been identified as one cause of autosomal recessive retinitis pigmentosa.

                                     
  • subunit beta is the beta subunit of the protein complex PDE 6 that is encoded by the PDE 6 B gene. PDE 6 is crucial in transmission and amplification of visual
  • is encoded by the PDE 6 D gene. PDE 6 D was originally identified as a fourth subunit of rod cell - specific cGMP phosphodiesterase PDE EC 3.1.4.35 The
  • phosphodiesterase subunit alpha is an enzyme that in humans is encoded by the PDE 6 C gene. GRCh38: Ensembl release 89: ENSG00000095464 - Ensembl, May 2017 GRCm38:
  • phosphodiesterase subunit gamma is an enzyme that in humans is encoded by the PDE 6 G gene. PDE 6 G has been shown to interact with Beta adrenergic receptor kinase and
  • for PDE 5. Its effect is more potent on PDE 5 than on other known phosphodiesterases 10 - fold for PDE 6 80 - fold for PDE 1, 700 - fold for PDE 2, PDE 3, PDE 4
  • phosphodiesterase type 5 inhibitor PDE 5 inhibitor is a drug used to block the degradative action of cGMP - specific phosphodiesterase type 5 PDE 5 on cyclic GMP in the
  • by the PDE 4A gene. The protein encoded by this gene belongs to the cyclic nucleotide phosphodiesterase PDE family, and PDE 4 subfamily. This PDE hydrolyzes
  • The PDE 2 phosphodiesterase 2 enzyme is one of 21 different phosphodiesterases PDE found in mammals. These different PDEs can be subdivided to 11 families
  • encoded by the PDE 10A gene. Various cellular responses are regulated by the second messengers cAMP and cGMP. Phosphodiesterases, such as PDE 10A, eliminate