ⓘ GRID2

                                     

ⓘ GRID2

Glutamate receptor, ionotropic, delta 2, also known as GluD2, GluRδ2, or δ 2, is a protein that in humans is encoded by the GRID2 gene. This protein together with GluD1 belongs to the delta receptor subtype of ionotropic glutamate receptors. They possess 14–24% sequence homology with AMPA, kainate, and NMDA subunits, but, despite their name, do not actually bind glutamate or various other glutamate agonists.

Delta iGluRs has long been considered orphan receptors, their endogenous ligands are unknown. They are now believed to bind glycine and D-serine, but they do not lead to the opening of the channel.

                                     
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