ⓘ UCN3

                                     

ⓘ UCN3

This gene is a member of the sauvagine/corticotropin-releasing factor/urotensin I family. It is structurally related to the corticotropin-releasing factor CRF gene and the encoded product is an endogenous ligand for CRF type 2 receptors.

In the brain it may be responsible for the effects of stress on appetite. He also expressed the beta cells in the pancreas and released together with insulin to promote somatostatin from the neighboring Delta cells, which provides a negative feedback on insulin secretion. Despite the gene family name similarity, the product of this gene has sequence similarity Urotensin-second.