ⓘ HAX1

                                     

ⓘ HAX1

HCLS1-associated protein X-1 is a protein that in humans is encoded by the HAX1 gene.

The protein encoded by this gene is known to be associated with T1, a substrate of src family tyrosine kinases. It also interacts with the product of PKD2 gene, mutations in which are associated with autosomal dominant polycystic kidney disease, and with F-actin-binding protein cortactin. Previously thought that this gene product is primarily localized in mitochondria, but recent studies indicate it to be localized in the cell body. Two transcripts encoding different isoforms have been found for this gene.

In 2015, localization of the protein With P-bodies were demonstrated.

                                     
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  • interactions with the mitochondrial GTPase optic atrophy 1 OPA 1 and the Bcl - 2 family - related protein HAX1 OPA 1 mainly regulates mitochondrial fusion in the mitochondrial
  • Heinrich Georg Heinz Hax 24 January 1900 1 September 1969 was a German modern pentathlete and sport shooter who competed in the 1932 Summer Olympics
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  • Kostmann disease which arises from homozygous mutations in the HAX1 gene on chromosome 1 p22. 1 About one third of SCN3 individuals also have neurological
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  • use a common needle type referred to as Groz - Beckert 130 705, HAx1 or 15x 1 needles. Needles labeled as universal needles are of this type and
  • suggest that IL - 1 α is as an epidermal cytokine. IL 1 A has been shown to interact with HAX1 and NDN. Although there are many interactions of IL - 1 α with other
  • function by acting as a protein chaperone. The interaction with protein like HAX1 suggests that human CLPB may be involved in apoptosis. In humans, the presence
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