ⓘ SETMAR

                                     

ⓘ SETMAR

SETMAR contains a SET domain that confers its histone methyltransferase activity, on Lys-4 and Lys-36 of Histone H3, both of which are specific tags for epigenetic activation. It has been identified as a repair protein as it mediates dimethylation at Lys-36 at double-strand break locations, a signal enhancing NHEJ repair.

Anthropoid primates, including humans, have a version of the protein were fused to the Mariner / TC1 transposase. This fusion of the region is the DNA-binding capacity of the protein, and the activity of some nucleases. The activity of the transposase is lost due to mutations D610N, but the domain can still be recognized Mariner repeat elements and introduce nicks in the DNA.

                                     
  • subfamilies. Although both types are inactive, one copy of Hsmar1 found in the SETMAR gene is under selection as it provides DNA - binding for the histone - modifying
  • SETD1A, SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETDB1, SETDB2, SETMAR SMYD1, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, SUV420H1, SUV420H2, WBP7
  • subfamilies. Although both types are inactive, one copy of Hsmar1 found in the SETMAR gene is under selection as it provides DNA - binding for the histone - modifying
  • SETD2, SETD3, SETD4, SETD5, SETD6, SETD7, SETD8, SETD9, SETDB1, SETDB2 SETMAR SMYD1, SMYD2, SMYD3, SMYD4, SMYD5, SUV39H1, SUV39H2, SUV420H1, SUV420H2