ⓘ SETD2

                                     

ⓘ SETD2

SETD2 protein is a histone methyltransferase that is specific for lysine-36 of histone H3, and methylation of this residue is associated with active chromatin. This protein also contains a novel transcriptional activation domain and has been found associated with hyperphosphorylated RNA polymerase II.

In trimethylation of lysine-36 of histone H3 H3K36me3 is required in human cells for homologous recombinant repair and genome stability. Depletion of SETD2 increases the frequency of deletion mutations that occur alternative process of DNA repair, microhomology-mediated end.

                                     
  • domain containing 6 is a protein in humans that is encoded by the SETD 6 gene. SETD 6 monomethylates the RelA subunit of nuclear factor kappa B NF - κB
  • SET domain containing 3 SETD 3 is a protein that in humans is encoded by the SETD 3 gene. It is a methyl transferase implicated in the replication of
  • Histone - lysine N - methyltransferase SETD 7 is an enzyme that in humans is encoded by the SETD 7 gene. GRCh38: Ensembl release 89: ENSG00000145391 - Ensembl
  • encoded by the SETD 5 gene. Model organisms have been used in the study of SETD 5 function. A conditional knockout mouse line called Setd 5tm1a EUCOMM Wtsi
  • survival. It also recruits a SET 2 histone methyltransferase Huntingtin - interacting protein HYPB, also known as SETD2 to RNAPII during transcription
  • frequently mutated genes were discovered in CCRCC: VHL, KDM6A UTX, SETD2 KDM5C JARID1C and MLL 2 PBRM1 is also commonly mutated in CCRCC. CCRCC is derived from
  • EHMT 2 EZH1, EZH 2 FP13812 MLL, MLL 2 MLL3, MLL5 NSD1 PRDM1, PRDM 2 PRDM5 SETD 1A, SETD2 SETD 3, SETD 4, SETD 5, SETD 6, SETD 7, SETD 8, SETDB1, SETDB 2 SETMAR
  • EHMT1, EHMT 2 EZH1, EZH 2 MLL, MLL 2 MLL3, MLL4, MLL5 NSD1 PRDM 2 SET, SETBP1, SETD 1A, SETD 1B, SETD2 SETD 3, SETD 4, SETD 5, SETD 6, SETD 7, SETD 8, SETD 9, SETDB1
  • SETD provides federally funded rural intercity bus services in Clatsop County, Oregon. Sunset Empire Transportation is also known as The Bus SETD
  • damage such as double - strand breaks. The trimethylation is catalyzed by SETD2 methyltransferase. H3K36me3 acts as a mark for HDACs to bind and deacetylate
  • first researcher in the world to link the SET domain containing protein 2 SETD2 gene to human breast cancer. He has also written 14 books in various disciplines