ⓘ ZWINT

                                     

ⓘ ZWINT

Zwint-1 is clearly involved in kinetochore function although an exact role is not known. It interacts with ZW10, another kinetochore protein, possibly regulating the association between ZW10 and kinetochores. The encoded protein localizes to prophase kinetochores before ZW10 does and it remains detectable on the kinetochore until late anaphase. It has a uniform distribution in the cytoplasm of interphase cells. Alternatively spliced transcript variants encoding different isoforms have been found for this gene.

                                     
  • encoded by the MIS12 gene. MIS12 has been shown to interact with NSL1, ZWINT CASC5, Polyamine - modulated factor 1, NDC80, DSN1 and CBX5. GRCh38: Ensembl
  • humans encoded by the DSN1 gene. DSN1 along with MIS12, DC8, PMF1, CBX5, ZWINT is a component of the kinetochore - associated multiprotein complex which
  • humans is encoded by the RAB3C gene. Rab3C has been show to interact with ZWINT GRCh38: Ensembl release 89: ENSG00000152932 - Ensembl, May 2017 GRCm38:
  • complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint - 1 Nature Cell Biology. 6 11 1135 41. doi: 10.1038 ncb1187. PMID 15502821
  • development. CASC5 has been shown to interact with MIS12, BUB1, BUBR1 and ZWINT - 1. Homozygous polymorphisms in the CASC5 gene have been seen in patients
  • Chan G February 2008 Stable hZW10 kinetochore residency, mediated by h Zwint - 1 interaction, is essential for the mitotic checkpoint J. Cell Biol. 180
  • complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint - 1 Nat. Cell Biol. England. 6 11 1135 41. doi: 10.1038 ncb1187. ISSN 1465 - 7392
  • complex is linked to heterochromatic HP1 and outer kinetochore protein Zwint - 1 Nature Cell Biology. 6 11 1135 41. doi: 10.1038 ncb1187. PMID 15502821