ⓘ USP4

                                     

ⓘ USP4

Ubiquitin specific protease 4 is an enzyme that cleaves ubiquitin from a number of protein substrates. Prior to the standardization of nomenclature USP4 was known as UNP, and was one of the first deubiquitinating enzymes to be identified in mammals. In the mouse and human the USP4 protein is encoded by a gene containing 22 exons.

This protein is a member of cysteine peptidase family C19. As unusual deubiquitinating enzyme that has the ability to cleave the ubiquitin-Proline bond. This property can reflect structural flexibility in the active site of the enzyme, and can be explained by its ability to cleave ubiquitin chains of different linkages. USP4 and substrates an important function in several signaling pathways of the cell, including NF-KB, TGF-β signaling pathway Wnt / β-catenin, p53 and the spliceosome way. Other substrates include adenosine A2A receptor and Ro52 TRIM21 protein.

USP4 is a nucleocytoplasmic shuttling protein that has a functional nuclear localization signal NLS in QPQKKKK 766 772 and nuclear export signal nes 133 VEVYLLELKL 142. These signals initiate the USP4 translocation into the nucleus from cytoplasm and Vice versa, respectively. The proportion of cytoplasm to nuclear USP4 pool varies depending on the cell type, stage of the cell cycle and the expression level of the protein.

                                     
  • homology with USP 15 and along with USP4 forms the DU subfamily. Nevertheless, alignment of the three USPs confirms that USP 15 and USP4 are the closest
  • Baker RT 2005 Nuclear - cytoplasmic shuttling of the oncogenic mouse UNP USP4 deubiquitylating enzyme J. Biol. Chem. 280 1 745 52. doi: 10.1074 jbc
  • The USP Universelle Selbstladepistole or universal self - loading pistol is a semi - automatic pistol developed in Germany by Heckler Koch GmbH H K
  • protease USP UBP superfamily USP 1, USP 2, USP 3, USP4 USP 5, USP 6, USP 7, USP 8, USP 9X, USP 9Y, USP 10, USP 11, USP 12, USP 13, USP 14, USP 15, USP 16, USP 17, USP 17L2
  • an enzyme that in humans is encoded by the USP 6 gene. Aneurysmal bone cyst can be associated with a TRE17 USP 6 translocation. GRCh38: Ensembl release 89:
  • unnilpentium, for the chemical element Dubnium A synonym for the enzyme USP4 University Nanosatellite Program National University of the Patagonia San
  • hydrolase 20 is an enzyme that in humans is encoded by the USP 20 gene. Ubiquitin - specific protease 20 USP 20 also known as ubiquitin - binding protein 20 and
  • Ubiquitin - specific - processing protease 7 USP 7 also known as ubiquitin carboxyl - terminal hydrolase 7 or herpesvirus - associated ubiquitin - specific protease
  • Ubiquitin - specific protease 14 is an enzyme that in humans is encoded by the USP 14 gene. This gene encodes a member of the ubiquitin - specific processing UBP