ⓘ SUMF1

                                     

ⓘ SUMF1

Sulfatase-modifying factor 1 is an enzyme that in humans is encoded by the SUMF1 gene.

Sulfatases catalyze hydrolysis of sulfate esters such as glycosaminoglycans, sulfolipids, and steroid sulfates. C-alpha-formylglycine FGly, catalytic residues in the active center of eukaryotic sulfatases, is posttranslationally generated from a cysteine SUMF1 human form of aerobic Formylglycine-generating enzyme FGR, in endoplasmic reticulum er. The genetic defect of FGly formation caused by mutations in SUMF1 results the gene is not active in FGR, and subsequently, multiple sulfatase deficiency MSD MIM 272200, lysosomal storage disorders roeser et al. 2006.

                                     
  • topology found in the gene product of human sulfatase - modifying factor 1 SUMF1 Aerobic FGE converts a cysteine residue in the highly conserved consensus
  • PMID 12975309. Landgrebe J, Dierks T, Schmidt B, von Figura K 2004 The human SUMF1 gene, required for posttranslational sulfatase modification, defines a new
  • Multiple sulfatase deficiency is thought to be caused by any mutation of the SUMF1 gene which would render its protein product, the formylglycine - generating
  • Heterozygous deletion of ITPR 1 but not SUMF1 in spinocerebellar ataxia type 16 Journal of Medical Genetics. 45 1 32 5. doi: 10.1136 jmg.2007.053942
  • Potential of Morin in Ovalbumin - induced Allergic Asthma Via Modulation of SUMF 2 IL - 13 and BLT2 NF - kB Signaling Pathway Current Molecular Pharmacology
  • of Adeno - Associated Viral Vector Serotype rh.10 Carrying Human SGSH and SUMF1 cDNAs in Children with Mucopolysaccharidosis Type IIIA Disease: Results
  • serine threonine tyrosine - interacting - like protein 1 SUMF 2: sulatase - modifying factor 2 SYPL 1 synaptophysin - like protein 1 TARP: TCR gamma alternate reading frame