ⓘ SENP6

                                     

ⓘ SENP6

Ubiquitin-like molecules UBLs, such as SUMO1, are structurally related to ubiquitin and can be ligated to target proteins in a similar manner as ubiquitin. However, covalent attachment of UBLs does not result in degradation of the modified proteins. SUMO1 modification is implicated in the targeting of RANGAP1 to the nuclear pore complex, as well as in stabilization of I-kappa-B-alpha NFKBIA, MIM 164008 from degradation by the 26S proteasome. Like ubiquitin, UBLs are synthesized as precursor proteins, with 1 or more amino acids following the C-terminal glycine-glycine residues of the mature UBL protein. Thus, the tail sequences of the UBL precursors need to be removed by UBL-specific proteases, such as SENP6, prior to their conjugation to target proteins

                                     
  • specific peptidase 3, also known as SENP 3, is a protein which in humans is encoded by the SENP 3 gene. SENP 3 together with SENP 5, belongs to the Ulp1 branch in
  • encoded by the SENP 2 gene. SUMO1 UBL1 MIM 601912 is a small ubiquitin - like protein that can be covalently conjugated to other proteins. SENP 2 is one of
  • Sentrin - specific protease 7 is an enzyme that in humans is encoded by the SENP 7 gene. GRCh38: Ensembl release 89: ENSG00000138468 - Ensembl, May 2017 GRCm38:
  • disorder 5 SEN 6 senescence cellular - related 6 SENP6 SUMO1 sentrin specific peptidase 6 6 q14.1 SERAC1: serine active site containing 1 6 q25.3 SERINC1:
  • containing multiple XFXFG repeats. NUP153 has been shown to interact with SENP 2 and KPNB1. GRCh38: Ensembl release 89: ENSG00000124789 - Ensembl, May 2017
  • basis for SUMO protease specificity provided by analysis of human Senp 2 and a Senp 2 - SUMO complex Structure. 12 8 1519 31. doi: 10.1016 j.str.2004
  • transport to the nucleolus. Its regulation through SUMOylation by SENP 3 and SENP 5 is another facet of the proteins s regulation and cellular functions
  • an exciting and novel target for heart failure treatment in the future. SENP6 GRCh38: Ensembl release 89: ENSG00000116030 - Ensembl, May 2017 GRCm38:
  • recently been correlated with increased expression of the genes ANP32D and SENP 1. CMS is characterised by polycythaemia with subsequent increased haematocrit