ⓘ Collagen, type XIII, alpha 1

                                     

ⓘ Collagen, type XIII, alpha 1

Collagen alpha-1 chain is a protein that in humans is encoded by the COL13A1 gene.

This gene encodes the alpha chain of one of the nonfibrillar collagens. The function of this gene product is not known, however, it was discovered in small quantities in the connective tissue-producing cells so it may serve a General function in connective tissues. In contrast to the collagens, which are secreted in the extracellular matrix, collagen XIII contains the transmembrane domain and the protein was localized in the plasma membrane. Transcripts for this gene undergo complex and extensive splicing with the participation of at least eight exons. Like other collagen XIII is a trimer, it is not known whether this trimer consists of one or more alpha-isomer chain. A number of alternative spliced transcripts variants have been described, but the full length was not determined. Collagen XIII belongs to the transmembranous subfamily of collagens, such as collagen XVII, XXIII and XXV.