ⓘ BNIP3L

                                     

ⓘ BNIP3L

This gene is a member of the BCL2/adenovirus E1B 19 kd-interacting protein BNIP family. It interacts with the E1B 19 kDa protein which is responsible for the protection of virally induced cell death, as well as E1B 19 kDa-like sequences of BCL2, also an apoptotic protector. The protein encoded by this gene is a functional homolog of BNIP3, a proapoptotic protein. This protein may function simultaneously with BNIP3 and may play a role in tumor suppression.

                                     
  • O Sullivan et al. found that BNIP 3 and BNIP3L play a necessary role in promoting NK cell memory formation. Expression of BNIP 3 in NK cells is lowered upon
  • in humans is encoded by the BNIP 2 gene. This gene is a member of the BCL2 adenovirus E1B 19 kd - interacting protein BNIP family. Though the specific
  • crystallography in the cases of STEAP 3 and STEAP4 PDB: 2VNS, 2VQ 3 and 2YJZ STEAP 3 has been shown to interact with BNIP3L and PKMYT1. GRCh38: Ensembl release
  • Letters. 540 1 3 86 90. doi: 10.1016 S0014 - 5793 03 00229 - 1. PMID 12681488. Zhou YT, Soh UJ, Shang X, Guy GR, Low BC Mar 2002 The BNIP - 2 and Cdc42GAP
  • PMID 10551883. Low BC, Seow KT, Guy GR December 2000 The BNIP - 2 and Cdc42GAP homology domain of BNIP - 2 mediates its homophilic association and heterophilic
  • been shown to interact with: BAK1, BCAP31, BCL2 - like 1, BCL2 L 11, BECN1, BID, BMF, BNIP 2, BNIP 3 BNIPL, BAD BAX, BIK, C - Raf, CAPN2, CASP8, Cdk1, HRK, IRS1
  • shown to interact with: APAF1, BAK1, BCAP31, BCL2 L 11, BNIP 3 BNIPL, BAD, BAX, BIK, Bcl - 2, HRK, IKZF 3 Noxa, PPP1CA, PSEN2 RAD9A, RTN1, RTN4, and VDAC1
  • cells. The BNIP 3 pathway involves mitochondrial release and nuclear translocation of the endonuclease G. It is not clear, however, that how BNIP 3 interacts
  • Boyd JM, Chinnadurai G 1999 BNIP 3 alpha: a human homolog of mitochondrial proapoptotic protein BNIP 3 Cancer Res. 59 3 533 7. PMID 9973195. Wang HG
  • Tang S, Bao L Shen L Yuan H, Zhao X, Lu H Jun 2008 Acetyl - Coenzyme A acyltransferase 2 attenuates the apoptotic effects of BNIP 3 in two human cell
  • induces apoptosis in various cancer cell lines by direct transactivation of BNIP3L and BAK Oncogene. 22 14 2172 85. doi: 10.1038 sj.onc.1206222. PMID 12687019