ⓘ REV3L

                                     

ⓘ REV3L

Protein reversionless 3-like also known as DNA polymerase zeta catalytic subunit is an enzyme that in humans is encoded by the REV3L gene.

In subunit Rev3 with Rev7 interacts to form floor z, the family B polymerase. Paul ζ lacks 3 to 5 exonuclease activity and polymerase reasonable accuracy. It cannot add nucleotides from DNA damage, but it can extend from primers with terminal mismatches. It makes the floor of ζ is very important in translesion synthesis TLS because it can act in concert with other TLS polymerases that can add to a hearth to complete the bypass of the lesion. Most polymerases have difficulty extending mismatches because they cannot bind properly to the mismatched DNA. So, not dying cells, it can survive, albeit with a mutation that may or may not be harmful, therefore, it is considered that Pol ζ is the driving force of evolution.

                                     
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