ⓘ RAB11FIP5

                                     

ⓘ RAB11FIP5

Rab11FIP5 is one of the many proteins that have been shown to interact with the Rab11 protein. Rab GTPases, such as Rab11, are enzymes that are involved in vesicular trafficking. Rab11 specifically plays a key role in endocytic trafficking and recycling through guiding early endosomes to endosome recycling complexes. Rab11FIP5, like most other Rab11FIP proteins, interacts with Rab11 by serving as an adaptor protein. This leads to downstream changes with regards to which proteins can interact. This is a result of the various Rab11FIP proteins that each have different binding partners. This process allows for the coordination and organization of endosomal transport and ultimately gives Rab11 its versatile function in the cell. It is believed that Rab11 recruits specific Rab11FIP proteins to the surface of vesicles in order to determine how the vesicle will behave.

Studies have shown that Rab11FIP5 is localized in the perinuclear endosome, where it helps in the bubble sort in slow path processing. This process includes the transport of cargo proteins, as endocytosed receptors in the endosome, processing complexes and subsequently to the plasma membrane. This is in contrast to the quick constituent route processing, which allows for direct transport of cargo from the endosome to the plasma membrane. Rab11FIP5 AIDS in the sorting process by binding to kinesin II and forming a protein complex for the regulation of vesicular transport. Some of the proteins that are regulated through Rab11FIP5 mediated trafficking of vesicles are microtubule proteins and receptors TFR. This one function Rab11FIP5 in the cell cytoskeleton and the absorption of iron from the cells, respectively.

                                     
  • Rab 11 family - interacting protein 3 is a protein that in humans is encoded by the RAB 11 FIP 3 gene. Proteins of the large Rab GTPase family see RAB 1A MIM
  • Rab 11 family - interacting protein 4 is a protein that in humans is encoded by the RAB 11 FIP 4 gene. RAB 11 FIP 4 has been shown to interact with RAB 11 A. GRCh38:
  • Rab 11 family - interacting protein 2 is a protein that in humans is encoded by the RAB 11 FIP 2 gene. RAB 11 FIP 2 has been shown to interact with MYO 5 B, RAB 11A
  • Rab 11 family - interacting protein 1 Rab 11 - FIP 1 also known as Rab - coupling protein is a protein that in humans is encoded by the RAB 11 FIP 1 gene. Proteins
  • signalling RAB11A has been shown to interact with: RAB 11 FIP 1, RAB 11 FIP 2, RAB 11 FIP 3, RAB 11 FIP 4, and RAB11FIP5 GRCh38: Ensembl release 89: ENSG00000103769
  • promoter of tumor development. RAB25 has been shown to interact with RAB 11 FIP 2 and RAB11FIP5 GRCh38: Ensembl release 89: ENSG00000132698 - Ensembl, May 2017
  • experiments with Rab 11 a b and Rab 11 - interacting proteins FIPs indicate that FIPs cannot differentiate between GTP - bound Rab 11 a and Rab 11 b in vitro. The
  • Entrez Gene: RAB 8A RAB 8A, member RAS oncogene family Hattula K, Peranen J 2000 FIP - 2, a coiled - coil protein, links Huntingtin to Rab 8 and modulates
  • Ras - related protein Rab - 4A is a protein that in humans is encoded by the RAB 4A gene. RAB 4A has been shown to interact with: CD2AP, KIF3B, RAB 11 FIP 1, RABEP1, and
  • PLCL1 PLCL2 PLCZ1 PRF1 PRKCA PRKCB1 PRKCE PRKCG PRKCH RAB 11 FIP 1 RAB 11 FIP 2 RAB11FIP5 RASA1 RASA2 RASA3 RASA4 RASAL1 RASAL2 RGS3 RIMS1 RIMS2
  • MYO5B has also been associated with bipolar disorder. MYO 5 B has been shown to interact with RAB 11 FIP 2. GRCh38: Ensembl release 89: ENSG00000167306 - Ensembl
  • and even the subcellular location of Rab 11 - FIP 2 changed. Therefore, a coordinated role for EHD proteins and Rab 11 - FIP 2 has been found in mediating endocytic