ⓘ ARFGEF1

                                     

ⓘ ARFGEF1

ADP-ribosylation factors ARFs play an important role in intracellular vesicular trafficking. The protein encoded by this gene is involved in the activation of ARFs by accelerating replacement of bound GDP with GTP. It contains a Sec7 domain, which may be responsible for the guanine-nucleotide exchange activity and also the brefeldin A inhibition.

                                     
  • exchange activity and also brefeldin A inhibition. ARFGEF 2 has been shown to interact with ARFGEF1 PRKAR 1 A and PRKAR2A. GRCh38: Ensembl release 89: ENSG00000124198
  • has been shown to interact with: AKAP10, AKAP1, AKAP4, ARFGEF1 ARFGEF 2, Grb2, MYO7A, PRKAR 1 B, and UBE2M. cAMP - dependent protein kinase GRCh38: Ensembl
  • this gene has not been determined. FKBP2 has been shown to interact with ARFGEF1 and EPB41L2. GRCh38: Ensembl release 89: ENSG00000173486 - Ensembl, May
  • PE, Shugart YY, Imitola J, Khoury SJ, Guerrini R, Walsh CA. Mutations in ARFGEF 2 implicate vesicle trafficking in neural progenitor proliferation and migration
  • hydrolase ARFGEF 2: ADP - ribosylation factor guanine nucleotide - exchange factor 2 brefeldin A - inhibited BCAS 1 Breast carcinoma - amplified sequence 1 BLCAP:
  • to interact with: AKAP11, AKAP13, AKAP 1 AKAP2, AKAP3, AKAP8, AKAP9, ARFGEF 2, CBFA2T3 GSK3B, PDE4A, and RUNX 1 T 1 Protein kinase AMPK cAMP GRCh38: Ensembl