ⓘ WNT1-inducible-signaling pathway protein 3

                                     

ⓘ WNT1-inducible-signaling pathway protein 3

It is a member of the CCN family CCN intercellular signaling protein of secreted, extracellular matrix ECM-associated signaling matricellular proteins. The CCN acronym is derived from the first three members of the family identified, namely CYR61 cysteine-rich angiogenic inducer 61, or CCN1, CTGF connective tissue growth factor, or CCN2, and NOV nephroblastoma overexpressed, or CCN3. These proteins, together with WISP1 CCN4, and WISP2 CCN5 comprise the six-member CCN family in vertebrates. CCN proteins characteristically contain an N-terminal secretory signal peptide followed by four structurally distinct domains with homologies to insulin-like growth factor binding protein IGFBP, von Willebrand type C repeats vWC, thrombospondin type 1 repeat TSR, and a cysteine knot motif within the C-terminal CT domain.

                                     
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  • WNT1 inducible signaling pathway protein - 1 CCN5: WISP2 WNT1 inducible signaling pathway protein - 2 CCN6: WISP 3 WNT1 inducible signaling pathway protein - 3
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