ⓘ SCYL1

                                     

ⓘ SCYL1

This gene encodes a transcriptional regulator belonging to the SCY1-like family of kinase-like proteins. The protein has a divergent N-terminal kinase domain that is thought to be catalytically inactive, and can bind specific DNA sequences through its C-terminal domain. It activates transcription of the telomerase reverse transcriptase and DNA polymerase beta genes. The protein has been localized to the nucleus, and also to the cytoplasm and centrosomes during mitosis. Multiple transcript variants encoding different isoforms have been found for this gene. At least three of the transcripts code for a protein containing all exons, referred to as full-length FL.

The mouse homolog of FL-Scyl1 is 90% identical and 93% similar on the amino acid composition of human FL-Scyl1. MNU van FL-Scyl1 encodes an 806-amino acid polypeptide. FZ protein contains heat repeats and a C-terminal coiled coil domain, which also contains several dibasic motifs, and ends in a dibasic motif RKLD-COOH.

Scyl1 is localized to CIS-Golgi and er-Golgi intermediate compartment ERGIC. Scyl1 binds COPI Coatomer I and colocalizes with beta-Kopi and ERGIC53. siRNA mediated knockdown of protein is broken reverse current of the kdel receptor from the Golgi to the er. In addition, Scyl1 localization in hippocampal neurons of rats also shows a similar relationship to mine.