ⓘ GLRX2

                                     

ⓘ GLRX2

Glutaredoxin 2 is an enzyme that in humans encoded by the GLRX2 gene. GLRX2, also known as GRX2, is a glutaredoxin family protein and a thiol-disulfide oxidoreductase that maintains cellular thiol homeostasis. This gene consists of four exons and three introns, spanned 10 kilobase pairs, and localized to chromosome 1q31.2–31.3.

GLRX2 alternative splicing leads to three isoforms of Grx2. One isoform, Grx2a, is localized in the mitochondria, is widely expressed in tissues, regulates mitochondrial redox homeostasis and protects cells from oxidative stress. Isoforms Grx2b and Grx2c, both localized in the nucleus and cytosol, is expressed only in testes and cancer cell lines and promote cell differentiation and transformation, potentially causing tumor progression.

                                     
  • Glutaredoxin 5, also known as GLRX 5, is a protein which in humans is encoded by the GLRX 5 gene located on chromosome 14. This gene encodes a mitochondrial
  • Glutaredoxin - 3 is a protein that in humans is encoded by the GLRX 3 gene. GLRX 3 has been shown to interact with PRKCQ. GRCh38: Ensembl release 89: ENSG00000108010
  • Glutaredoxin - 1 is a protein that in humans is encoded by the GLRX gene. GLRX has been shown to interact with Wilson disease protein and ATP7A. GRCh38:
  • including the response to oxidative stress. These enzymes are not related to GLRX2 Vlamis - Gardikas A, Potamitou A, Zarivach R, Hochman A, Holmgren A 2002
  • and glutathione. Glutaredoxin subgroup InterPro: IPR014025 GLRX GLRX2 GLRX 3 GLRX 5 PTGES 2 Holmgren A, Gleason FK 1988 Thioredoxin and related proteins
  • this domain include: DNAJC10 ERP70 GLRX 3 P4HB P5 PDIA 2 PDIA3 PDIA4 PDIA5 PDIA6 PDILT QSOX1 QSOX 2 STRF8 TXN TXN 2 TXNDC1 TXNDC10 TXNDC11 TXNDC13
  • interacts with glutaredoxin - 1 GLRX Subsequent transport is promoted through the reduction of intramolecular disulfide bonds by GLRX catalysis. Wilson disease
  • hyperglycinemia is caused by mutations in LIAS, BOLA3 and the novel gene GLRX 5 Brain. 137 Pt 2 366 79. doi: 10.1093 brain awt328. PMC 3914472. PMID 24334290
  • these proteins. DNAJC10 ERP70 GLRX 3 P4HB PDIA 2 PDIA3 PDIA4 PDIA5 PDIA6 PDILT PDIP QSOX1 QSOX 2 STRF8 TXN TXN 2 TXNDC1 TXNDC10 TXNDC11 TXNDC13
  • Hereditary or congenital sideroblastic anemia may be X - linked or autosomal. GLRX 5 has also been implicated. Acquired, or secondary, sideroblastic anemia develops