ⓘ QARS

                                     

ⓘ QARS

Aminoacyl-tRNA synthetases catalyze the aminoacylation of tRNA by their cognate amino acid. Because of their central role in linking amino acids with nucleotide triplets contained in tRNAs, aminoacyl-tRNA synthetases are thought to be among the first proteins that appeared in evolution. In metazoans, 9 aminoacyl-tRNA synthetases specific for glutamine gln, glutamic acid glu, and 7 other amino acids are associated within a multienzyme complex. Although present in eukaryotes, glutaminyl-tRNA synthetase QARS is absent from many prokaryotes, mitochondria, and chloroplasts, in which Gln-tRNAGln is formed by transamidation of the misacylated Glu-tRNAGln. Glutaminyl-tRNA synthetase belongs to the class-I aminoacyl-tRNA synthetase family. Almost all eukaryotic GlnRS enzymes possess a YqeY domain at the N-terminus, which affects affinity for the tRNA, in some bacterial species, such as Deinococcus radiodurans, YqeY is present as a C-terminal domain with similar function.

                                     
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