ⓘ BTAF1

                                     

ⓘ BTAF1

Initiation of transcription by RNA polymerase II requires the assistance of TATA box-binding protein TBP, MIM 600075 and TBP-associated factors, or TAFs e.g., TAF2B, MIM 604912, in 2 distinct complexes, TFIID and B-TFIID. The TFIID complex is composed of TBP and more than 8 TAFs. However, the majority of TBP is present in the B-TFIID complex, which is composed of TBP and TAFII170, also called TAF172, and has DNA-dependent ATPase activity.

                                     
  • PMID 1907890. NCBI Entrez GeneID: 9044 BTAF1 BTAF1 RNA polymerase II, B - TFIID transcription factor - associated, 170kDa Mot 1 homolog, S. cerevisiae Timmers
  • S, Meisterernst M, Timmers HT November 2004 NC2alpha interacts with BTAF1 and stimulates its ATP - dependent association with TATA - binding protein
  • include CARM 1 CBP and EP300. Many coactivators also function as corepressors under certain circumstances. Cofactors such as TAF 1 and BTAF1 can initiate
  • transcription factors: TFIIA GTF2A 1 GTF2A2 TFIIB GTF2B B - TFIID BTAF1 TBP TFIID BTAF1 BTF3, BTF3L4, EDF 1 TAF 1 - 15, 16 total TFIIE, TFIIF, TFIIH
  • with: BRF 1 BTAF1 C - Fos, C - jun, EDF 1 GTF2B TFIIB GTF2A 1 TFIIA subunit 1 GTF2F 1 TFIIF subunit 1 GTF2H4 TFIIH subunit 4 Mdm2, MSX 1 NFYB, P53