ⓘ FGF18

                                     

ⓘ FGF18

Fibroblast growth factor 18 is a protein that in humans is encoded by the FGF18 gene.

The protein encoded by this gene is a member of a family of fibroblast growth factor FGF. The FGF family members possess broad mitogenic and survival activities of cells and are involved in various biological processes, including embryonic development, cell growth, morphogenesis, tissue repair, tumor growth and invasion. It was shown in vitro that this protein is able to induce neurite outgrowth from pc12 cells. FGF18 signals through receptor fibroblast growth factor FGFR3 to promote chondrogenesis was shown to cause thickening of the cartilage in a mouse model of osteoarthritis and a recombinant version sprifermin undergoing clinical trials as a potential treatment for osteoarthritis. Studies of similar proteins in mouse and chick suggested that this protein is a pleiotropic growth factor that stimulates proliferation in several tissues, especially liver and small intestine. Knockout studies of the similar gene in mice implied the role of this protein in the regulation of proliferation and differentiation of midline structures of the cerebellum.

                                     
  • recombinant human fibroblast growth factor 18 rh FGF 18 is a recombinant form of human fibroblast growth factor 18 FGF18 which is under development by Merck
  • involvement in skeletal development and repair. FGF 9 and FGF18 both stimulate chondrocyte proliferation. FGF 9 heterozygous mutant mice had a compromised bone
  • involved in intracellular processes unrelated to the FGFs This group is also known as i FGF Human FGF18 is involved in cell development and morphogenesis
  • humans is encoded by the FGF 8 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 10 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 17 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 4 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • all seven principal FGFRs FGF7, however, can only activate FGFR2b, and FGF18 was recently shown to activate FGFR3. A gene for a fifth FGFR protein, FGFR5
  • humans is encoded by the FGF 12 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • Fibroblast growth factor 19 is a protein that in humans is encoded by the FGF 19 gene. It functions as a hormone, regulating bile acid synthesis, with effects
  • humans is encoded by the FGF 13 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess
  • humans is encoded by the FGF 14 gene. The protein encoded by this gene is a member of the fibroblast growth factor FGF family. FGF family members possess