ⓘ REV1

                                     

ⓘ REV1

DNA repair protein REV1 is a protein that in humans is encoded by the REV1 gene.

This gene encodes a protein with similarity to the S. cerevisiae mutagenesis protein Rev1. In ed. 1 protein contains a BRCT domain, which plays an important role in protein-protein interactions. The proposed role for the human Rev1-like protein is as a scaffold that recruits DNA polymerases involved in translesion synthesis TLS DNA damage. Two alternative spliced transcript variants that encode different proteins have been found.

Ed. 1 In G family DNA polymerase, it is sometimes called deoxycytidyl transferase because it only inserts a deoxycytidine DC from damage. Whether its G, A, T, C, or the abasic site, ed 1 will always add S. ed. 1 has the ability to always add that it uses arginine as a template, which is a good Supplement C. Yet it is believed that ed 1 rarely uses its polymerase activity, and it is believed that Rev1s main role is as a protein of the landing site, which she helps to direct the recruitment of these proteins, especially Paul ζ Rev3 / Rev7.

                                     
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