ⓘ ORC4

                                     

ⓘ ORC4

The origin recognition complex ORC is a highly conserved six subunit protein complex essential for the initiation of the DNA replication in eukaryotic cells. Studies in yeast demonstrated that ORC binds specifically to origins of replication and serves as a platform for the assembly of additional initiation factors such as Cdc6 and Mcm proteins. The protein encoded by this gene is a subunit of the ORC complex. It has been shown to form a core complex with ORC2L, -3L, and -5L. Three alternatively spliced transcript variants encoding the same protein have been reported.

                                     
  • origin of replication. ORC 2 has been shown to interact with: CDC6, DBF 4 MCM10, MCM2 MCM 4 MCM5, MCM6, MCM7, ORC 1, ORC 3, ORC4 ORC 5, ORC 6, and Replication
  • isoforms have been described. ORC 5 has been shown to interact with: MCM2, MCM3, MCM 4 MCM7, ORC 1, ORC 2, ORC 3, and ORC4 GRCh38: Ensembl release 89: ENSG00000164815
  • with cytokinesis. ORC 6 has been shown to interact with MCM5, ORC 2, Replication protein A1, ORC4 DBF 4 ORC 3, CDC45 - related protein, MCM 4 and Cell division
  • isoforms have been reported for this gene. ORC 3 has been shown to interact with: MCM 4 MCM7, ORC 2, ORC4 ORC 5, and ORC 6. GRCh38: Ensembl release 89: ENSG00000135336
  • 7 - related protein kinase, Cyclin - dependent kinase 2, MCM2, MCM 4 MCM6, MCM7, MYST2, ORC 2, ORC4 ORC 5, and SKP2. GRCh38: Ensembl release 89: ENSG00000085840
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