ⓘ CPSF1

                                     

ⓘ CPSF1

Cleavage and polyadenylation specificity factor subunit 1 is a protein that in humans is encoded by the CPSF1 gene.

In most cases eukaryotic pre-messengermRNA 3 Prime ends are processed in two coordinated steps. First, there is the site-specific cleavage using restriction enzyme, and then add the polya tail at the 3 Prime end to 5 Prime side of the product. Cleavage requires four multisubunit complexes, namely splitting and polyadenylation specificity factor CPSF, cleavage stimulation factor CstF, cleavage factors im and IIM CFIm and CFIIm, along with one polyApolymerase subunit of the PAP. CPSF1 is the largest component of the CPSF complex, composed of CPSF1, CPSF2, CPSF3, CPSF4, FIP1L1, Symplekin and WDR33 and is located in the nucleus.