ⓘ BCCIP

                                     

ⓘ BCCIP

BRCA2 and CDKN1A-interacting protein is a protein that in humans is encoded by the BCCIP gene.

This gene product was isolated based on its interaction with BRCA2 and P21 proteins. It is an evolutionary conserved nuclear protein with multiple interacting domains. The N-terminal half shares moderate homology with regions calmodulin and M-calpain, suggesting that it may also bind calcium. Functional studies indicate that this protein may be an important cofactor for BRCA2 in tumor suppression, and a modulator of CDK2 kinase activity via P21. Several variants of transcripts encoding different isoforms have been described for this gene.

                                     
  • BCCIP are PTPmu substrates. PKCδ activity is required for PTPmu mediated neurite outgrowth and PTPmu - mediated neurite repulsion. Expression of BCCIP is
  • to regenerate lost appendages. P21 has been shown to interact with: Nrf2 BCCIP CIZ1, CUL4A, CCNE1, CDK, DDB1, DTL, GADD45A, GADD45G, HDAC, PCNA, PIM1
  • mutations and cancer. BRCA2 has been shown to interact with BRE, BARD1, BCCIP BRCA1, BRCC3, BUB1B, CREBBP, C11orf30, FANCD2, FANCG, FLNA, HMG20B, P53
  • chaperone regulator 3 BANF1 BANF1 Barrier - to - autointegration factor BCCIP BCCIP BRCA2 And CDKN1A Interacting Protein BCLAF1 BCLAF1 BCL2 Associated Transcription
  • HGNC: 14367 Q8TDM0 1455 BCAT1 HGNC: 976 P54687 1456 BCAT2 HGNC: 977 O15382 1457 BCCIP HGNC: 978 Q9P287 1458 BCDIN3D HGNC: 27050 Q7Z5W3 1459 BCHE HGNC: 983 P06276