ⓘ ME1 (gene)

                                     

ⓘ ME1 (gene)

NADP-dependent malic enzyme is a protein that in humans is encoded by the ME1 gene.

This gene encodes cytosolic NADP -dependent enzyme that generates NADPH for the biosynthesis of fatty acids. The activity of this enzyme, the reversible oxidative decarboxylation of Malate to pyruvate, links to cycles of glycolysis and citric acid. The regulation of expression of this gene is complex. Increased expression can result from elevated levels of thyroid hormones or a high share of carbohydrates in the diet.