ⓘ KIF3A

                                     

ⓘ KIF3A

KIF3A is one subunit of the heterotrimeric motor protein, kinesin-2, that was initially isolated from sea urchin egg/embryo cytosol using microtubule affinity purification. This motor consists of two kinesin-related subunits called KIF3A and KIF3B or 3C in vertebrates and an associated protein KAP3, and it transports protein complexes, nucleic acids and organelles towards the "plus" ends of microtubule tracks within cells. Work done in a broad range of eukaryotic cells has revealed that heterotrimeric kinesin-2 is the primary motor protein driving the intra-flagellar transport of tubulins and other axonemal building blocks from the base of the ciliary/flagellar axoneme to their site of assembly at the distal tips. This process is required for cilium assembly/maintenance and cilium-based signalling which play key roles in various cell and developmental processes. For example, in vertebrate embryos, kinesin-2 function is required for cilia-dependent nodal flow and the development of left-right asymmetry.

                                     
  • First, KIF 3 B forms a heterodimer with KIF3A kinesin family member 3 A KIF3A 3 B that is membrane - bound and has ATPase activity. Then KAP 3 kinesin
  • et al. 1998 KIF 3 C and KIF3A form a novel neuronal heteromeric kinesin that associates with membrane vesicles Mol. Biol. Cell. 9 3 637 52. doi: 10
  • accessory subunit which co - oligomerizes with the motor subunits KIF3A and KIF 3 B or KIF 3 C, to form heterotrimeric kinesin - 2 motor proteins. Kinesin - 2 KAP
  • Kinesin heavy chain isoform 5A is a protein that in humans is encoded by the KIF 5A gene. This gene encodes a member of the kinesin family of proteins. Members
  • Kinesin - like protein KIF 1B is a protein that in humans is encoded by the KIF 1B gene. It is associated with Charcot Marie Tooth disease, type 2A1. KIF 1B has been
  • Kinesin - like protein KIF 17 is a protein that in humans is encoded by the KIF 17 gene. KIF 17 and its close relative, C. elegans OSM - 3 are members of the
  • Kinesin - like protein KIF 21A is a protein that in humans is encoded by the KIF 21A gene. KIF 21A belongs to a family of plus end - directed kinesin see MIM
  • protein KIF 1A, also known as axonal transporter of synaptic vesicles or microtubule - based motor KIF 1A, is a protein that in humans is encoded by the KIF 1A gene
  • Chromosome - associated kinesin KIF 4A is a protein that in humans is encoded by the KIF 4A gene. Kinesins, such as KIF 4A, are microtubule - based motor proteins
  • Kinesin - like protein KIF 2A is a protein that in humans is encoded by the KIF 2A gene. Kinesins, such as KIF 2, are microtubule - associated motor proteins