ⓘ CYP4A11

                                     

ⓘ CYP4A11

This gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. This protein localizes to the endoplasmic reticulum and hydroxylates medium-chain fatty acids such as laurate and myristate.

CYP4A11 is strongly expressed in the liver and kidneys.

Together with CYP4A11 CYP4A22, CYP4F2, and CYP4F3 metabolism of arachidonic acid to 20-Hydroxyeicosatetraenoic acid 20-hete by omega oxidation reactions with the predominant 20-hete-synthesizing enzymes in the human body, while CYP4A11 CYP4F2 subsequent, 20-hete regulates blood flow, blood flow, blood pressure, renal tubule absorption of ions in rodents and possibly humans. Variants of the gene polymorphism of CYP4A11 is associated with the development of hypertension and cerebral infarction, i.e., ischemic stroke in humans to see 20-Hydroxyeicosatetraenoic acid. In its ability to produce hydroxyl fatty acids, CYP4A11 is classified as monooxygease KDM.

CYP4A11 also has epoxygenase activity that he metablizes docosahexaenoic acid epoxydocosapentaenoic acids EDP in the first place, 19.20-epoxy isomers of eicosapentaenoic acid and eicosapentaenoic acid epoxyeicosatetraenoic acids EEQs primarily 17.18-function isomers. CYP4A11 converts arachidonic acid to epoxides. CYP4F8 and CYP4F12 have monooxygenase activity for arachidonic acid epoxygenase activity for eicosapentenoic and docosahexaenoic acids. In laboratory studies on human and animal cells and tissues and in vivo studies in animal models have shown that certain EEQs and edps is an action that often pitted against those of 20-hete, mainly in the areas of adjustment of blood pressure, arterial thrombosis, and cancer growth. These studies also show that EPA and EEQs are: 1) more powerful than CYP450 epoxygenase -epoxides are formed from arachidonic acid are called Eets in reducing hypertension and pain perception, 2) stronger or at least equal in potency of eets in the suppression of inflammation, and 3) act oppositely from eets in that they inhibit angiogenesis, migration of endothelial cells, endothelial cell proliferation, and the growth and metastasis of human breast and prostate cancer cell lines, while Eets have a stimulating effect in each of these systems. Consumption of omega-3 fatty acid-rich diet dramatically increases serum and tissue levels of EEQs and edps in animals and humans and in the human body are by far the most noticeable change in the profile of metabolites of polyunsaturated fatty acids, caused by biologically active omega-3 fatty acids.

Members of the CYP4A and CYP4F subfamily and CYP2U1 may also ω-the intestine is reduced, thereby reducing the activity of various fatty acids, metabolites of arachidonic acid, including LTB4, 5-hete, 5-oxo-eicosatetraenoic acid, 12-hete, and several of the prostaglandins involved in the regulation of various inflammatory, vascular and other reactions in animals and humans. This hydroxylation-induced inactivation may underlie the proposed role of cytochromes in the suppression of inflammatory reactions and associations of certain CYP4F2 and CYP4F3 single-nucleotide variants with human disease Krohns and celiac disease, respectively.

T8590C single-nucleotide polymorphism SNP, rs1126742 in CYPA411 gene produces a protein with significantly reduced catalytic activity due to the loss of the functions of the mechanism, this SNP was associated with hypertension in some but not all studies of the population. This result may be due to the reduction in the production of EEQs and EPD, which, as indicated above, the blood pressure lowering action.

                                     
  • possibly not as physiologically relevant as, other CYP 4 Fs such as CYP 4 F2, CYP 4 F3a, CYP 4 F3b, CYP4A11 and CYP 4 F2 in doing so. The enzyme also hydroxylates arachidonic
  • cytochrome P450 genes on chromosome 1p33. CYP 4 A22 was once considered, along with CYP4A11 CYP 4 F2, and CYP 4 F3, as active in metabolizing arachidonic acid
  • Another member of this family, CYP4F 11 is approximately 16 kb away. CYP 4 F2 along with CYP 4 A22, CYP4A11 and CYP 4 F3 and CYP 2U1 also metabolize arachidonic
  • which often oppose those of another product of CYP 450 enzymes e.g. CYP 4 A1, CYP4A11 CYP 4 F2, CYP 4 F3A, and CYP 4 F3B viz., 20 - Hydroxyeicosatetraenoic acid 20 - HETE
  • Cytochrome P450 3A 4 abbreviated CYP 3A 4 EC 1.14.13.97 is an important enzyme in the body, mainly found in the liver and in the intestine. It oxidizes
  • CYP 2S1 metabolizes PUFA to signaling molecules: it metabolizes AA to EETs ad EPA to EEQs. CYP 3A 4 metabolizes AA to EET signaling molecules. CYP4A11 metabolizes
  • CYP4A11 CYP 4 F3 is expressed as two distinct enzymes, CYP 4 F3A and CYP 4 F3B, due to alternative splicing of a single pre - mRNA precursor molecule CYP 4 F3A
  • Cytochrome P450 4 V2 is a protein that in humans is encoded by the CYP 4 V2 gene. Mutations are associated with Bietti s crystalline dystrophy and retinitis
  • Leukotriene - B 4 omega - hydroxylase 2 is an enzyme that in humans is encoded by the CYP 4 F3 gene. CYP 4 F3 encodes two distinct enzymes, CYP 4 F3A and CYP 4 F3B, which
  • Cytochrome P450 4 F8 is a protein that in humans is encoded by the CYP 4 F8 gene. This gene, CYP 4 F8, encodes a member of the cytochrome P450 superfamily of
  • Cytochrome P450 2D6 CYP 2D6 is an enzyme that in humans is encoded by the CYP 2D6 gene. CYP 2D6 is primarily expressed in the liver. It is also highly expressed