ⓘ ATP6V0A4

                                     

ⓘ ATP6V0A4

This gene encodes a component of vacuolar ATPase V-ATPase, a multisubunit enzyme that mediates acidification of intracellular compartments of eukaryotic cells. V-ATPase dependent acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis, and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane V0 domain. The V1 domain consists of three A and three B subunits, two G subunits plus the C, D, E, F, and H subunits. The V1 domain contains the ATP catalytic site. The V0 domain consists of five different subunits: a, c, c, c, and d. This gene is one of four genes in man and mouse that encode different isoforms of the a subunit. Alternatively spliced transcript variants encoding the same protein have been described. Mutations in this gene are associated with renal tubular acidosis associated with preserved hearing.

                                     
  • V - type proton ATPase 21 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP 6 V 0 B gene. This gene encodes a component of vacuolar ATPase
  • V - type proton ATPase 16 kDa proteolipid subunit is an enzyme that in humans is encoded by the ATP 6 V 0 C gene. This gene encodes a component of vacuolar ATPase
  • V - type proton ATPase 116 kDa subunit a isoform 2 also known as V - ATPase 116 kDa isoform a2 is an enzyme that in humans is encoded by the ATP 6 V 0 A2 gene
  • ATPase, H transporting, lysosomal 38kDa, V 0 subunit d2 is a protein in humans that is encoded by the ATP 6 V 0 D2 gene. It is part of proton pumps in the
  • V - type proton ATPase subunit d 1 is an enzyme that in humans is encoded by the ATP 6 V 0 D1 gene. This gene encodes a component of vacuolar ATPase V - ATPase
  • ATP6V1D, ATP 6 V 1E1, ATP 6 V 1E2, ATP 6 V 1F, ATP 6 V 1G1, ATP 6 V 1G2, ATP 6 V 1G3, ATP 6 V 1H, ATP 6 V 0 A1, ATP 6 V 0 A2, ATP6V0A4 ATP 6 V 0 B, ATP 6 V 0 C, ATP 6 V 0 D1, ATP 6 V 0 D2, ATP 6 V 0 E Cu
  • MT - ATP 6 or ATP 6 is a mitochondrial gene with the full name mitochondrially encoded ATP synthase membrane subunit 6 that encodes the ATP synthase Fo
  • V - type proton ATPase 116 kDa subunit a isoform 1 is an enzyme that in humans is encoded by the ATP 6 V 0 A1 gene. This gene encodes a component of vacuolar
  • V - type proton ATPase catalytic subunit A is an enzyme that in humans is encoded by the ATP 6 V 1A gene. This gene encodes a component of vacuolar ATPase V - ATPase