ⓘ ATP6V1B2

                                     

ⓘ ATP6V1B2

V-type proton ATPase subunit B, brain isoform is an enzyme that in humans is encoded by the ATP6V1B2 gene.

This gene encodes a component vacuolar ATPase V-ATPase, a multisubunit enzyme that mediates acidification of eukaryotic intracellular organelles. V-ATPase dependent organelle acidification is necessary for such intracellular processes as protein sorting, zymogen activation, receptor-mediated endocytosis and synaptic vesicle proton gradient generation. V-ATPase is composed of a cytosolic V1 domain and a transmembrane v0 domain. B1 domain consists of three B, and two G subunits, as well as C, D, E, F, and H subunit. V1 domain contains the ATP catalytic site. The protein encoded by this gene is one of two V1 domain b subunit isoforms and is the only isoform highly expressed in osteoclasts.

In melanocytic cells ATP6V1B2 gene expression may be regulated by MITF.