ⓘ SUMO4

                                     

ⓘ SUMO4

This gene is a member of the SUMO gene family. This family of genes encode small ubiquitin-related modifiers that are attached to proteins and control the target proteins subcellular localization, stability, or activity. The protein described in this record is located in the cytoplasm and specifically modifies IKBA, leading to negative regulation of NF-kappa-B-dependent transcription of the IL12B gene. A specific polymorphism in this SUMO gene, which leads to the M55V substitution, has been associated with type I diabetes. The RefSeq contains this polymorphism.

                                     
  • SUMOylation Cycle SUMO 1 homology group from HomoloGene human SUMO proteins on ExPASy: SUMO 1 SUMO 2 SUMO 3 SUMO4 UniProt entry for rat Sumo 1 Programs for prediction
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