ⓘ MAP3K4

                                     

ⓘ MAP3K4

Mitogen-activated protein kinase 4 is an enzyme that in humans is encoded by the MAP3K4 gene.

The Central core of each mitogen-activated protein kinase mark way is a conserved cascade of 3 protein kinases: an activated kinase Map-Kinas cascade MAPKKK and activates certain fosfauriliruet mark kinase MAPKK, which then activates a specific MAPK. While aktiviziruyutsya MAPKs Erk during mitogenic stimulation, the p38a CSBP2 and JNK MAPKs activated by environmental stresses such as osmotic shock, UV irradiation, wound stress and inflammatory factors. This gene encodes a MAPKKK in the MEKK4 protein, also called MTK1. The protein contains a protein kinase catalytic domain in the C Terminus. Domain N-terminal nonkinase may contain a regulatory domain. Expression of MEKK4 in mammalian cells activated the CSBP2 the p38a and JNK MAPK pathways, but not ERK pathway. In vitro kinase studies showed that recombinant MEKK4 can specifically fosfauriliruet PRKMK6 and activate MKK4 MKK6 and SERK1, MAPKKs that activate CSBP2 the p38a and JNK, respectively, but does not phosphorylate PRKMK1 MKK1 in MAPKK that activates Erks. MEKK4 is a major mediator of environmental stresses that activate P38 MAPK paths, and a minor mediator on the way of JNK. Two alternative spliced transcripts encoding different isoforms have been described.