ⓘ HAVCR1

                                     

ⓘ HAVCR1

Hepatitis A virus cellular receptor 1 also known as T-cell immunoglobulin and mucin domain 1 is a protein that in humans is encoded by the HAVCR1 gene.

It is also known as Kim-1 molecule kidney injury-1, which is a protein most strongly upregulated in the injured kidney different types of insults. Its regulation in renal injury was detected in the kidneys of vertebrates, such as zebrafish and human.

The hepatitis a virus cellular receptor 1 HAVCR1 / Tim-1 is a member of the Tim genetic family, which plays an important role in the regulation of immune cell activity, especially in relation to the host response to viral infection. Tim-1 is also involved in allergic reactions, asthma, and transplant tolerance.

The Tim gene family was first cloned from a mouse model of asthma in 2001. It was subsequently shown that the genetic members of the Tim family, including Tim-1 participate in host immune response. The mouse Tim gene family consists of eight members, Tim-1-8, while only three Tim genes have been identified in humans.

                                     
  • HAVCR 2 also known as T - cell immunoglobulin and mucin - domain containing - 3 TIM - 3 is a protein that in humans is encoded by the HAVCR 2 gene. HAVCR 2
  • HAPLN 1 HAPLN2 HAPLN3 HAPLN4 HAVCR1 HEPACAM HHLA2 HSPG2 ICOSLG IGHA 1 IGHA2 IGHD IGHG 1 IGHG3 IGHM IGHV 1 - 69 IGHV4 - 31 IGHV7 - 81 IGKC IGKV 1 - 5
  • the second lysosomal domain of NPC 1 that mediates this binding. The second candidate is TIM - 1 a.k.a. HAVCR1 TIM - 1 was shown to bind to the receptor
  • been found for this gene. Galectin - 9 is one of the most studied ligand for HAVCR 2 TIM - 3 and is expressed on various tumor cells. However, it can also interact