ⓘ GRK4

                                     

ⓘ GRK4

G protein-coupled receptor kinase 4 is an enzyme that in humans is encoded by the GRK4 gene.

This gene encodes a member of the G protein-binding receptor kinase subfamily of the SER / TP protein kinase family, and many are very similar to GRK5 and GRK6.

G-protein-binding receptor kinases phosphorylate activated G-protein-paired receptor, which promotes binding to the arrest of a protein receptor. To arrest the binding to active phosphorylated receptors prevents stimulation of the receptor heterotrimeric G protein transducer Proteins, blocking their cellular signaling and as a result of desensitization. To arrest the binding to active phosphorylated receptors also provides a receptor signaling through the arrest of protein partners. Thus, the system GRK / arrest serves as a signal switch for G-protein-paired receptors.

GRK4 is most strongly expressed in testes, with small amounts in the brain and in the kidney and other tissues and has four alternative spliced variants.

Polymorphisms in the GRK4 gene was associated with both genetic and acquired hypertension, operating under the dopamine receptors of the kidneys.

                                     
  • of the Ser Thr protein kinase family, and is most highly similar to GRK4 and GRK 5. The protein phosphorylates the activated forms of G protein - coupled
  • subfamily of the Ser Thr protein kinases, and is most highly similar to GRK4 and GRK 6. The protein phosphorylates the activated forms of G protein - coupled
  • structures have been obtained for several GRKs GRK 1, GRK 2, GRK4 GRK 5 and GRK 6 alone or bound to ligands. Overall, GRKs share sequence homology and domain
  • G - protein - coupled receptor kinase 2 GRK 2 is an enzyme that in humans is encoded by the ADRBK1 gene. GRK 2 was initially called Beta - adrenergic receptor
  • phosphorylation and uncoupling of the D1 receptor from its G protein effector GRK4 This impairs the kidney s renal sodium reabsorption, diuresis, and excretion
  • G - protein - coupled receptor kinase 3 GRK 3 is an enzyme that in humans is encoded by the ADRBK2 gene. GRK 3 was initially called Beta - adrenergic receptor
  • G - protein - coupled receptor kinase 7 EC 2.7.11.14, GRK 7, cone opsin kinase, iodopsin kinase is a serine threonine - specific protein kinase involved in
  • containing this domain include: AXIN1, AXIN2 GRK 1, GRK 2, GRK 3, GRK4 GRK 5, GRK 6, GRK 7 RGS1, RGS2, RGS3, RGS 4 RGS5, RGS6, RGS7, RGS8, RGS9, RGS10, RGS11
  • Visnjicevo Serbian Cyrillic: Вишњићево formerly Grk Serbian Cyrillic: Грк is a village located in the municipality of Sid, Serbia. As of 2011 census
  • Killeen Fort Hood Regional Airport IATA: GRK ICAO: KGRK, FAA LID: GRK is a small military commercial joint - use airport that operates alongside Robert
  • 14, rod opsin kinase, G - protein - coupled receptor kinase 1, GPCR kinase 1, GRK 1, opsin kinase, opsin kinase phosphorylating rhodopsin kinase phosphorylating