ⓘ AP1S1

                                     

ⓘ AP1S1

The protein encoded by this gene is part of the clathrin coat assembly complex which links clathrin to receptors in coated vesicles. These vesicles are involved in endocytosis and Golgi processing. This protein, as well as beta-prime-adaptin, gamma-adaptin, and the medium mu chain AP47, form the AP-1 assembly protein complex located at the Golgi vesicle. Two alternatively spliced transcript variants of this gene, which encode distinct isoforms, have been reported.

Mutations in AP1S1 causes a rare syndrome family Coppersmith described in 2008.

                                     
  • clathrin - associated protein complex AP - 1 The other components of this complex are beta - prime - adaptin, gamma - adaptin, and the small chain AP1S1 This complex is located
  • isoforms have been found for this gene. AP 1 G 1 has been shown to interact with: AP 1 B 1 AP 1 GBP 1 AP 1 M 1 AP1S1 NECAP2, RABEP 1 and Synaptophysin. GRCh38: Ensembl
  • Activator protein 1 AP - 1 is a transcription factor that regulates gene expression in response to a variety of stimuli, including cytokines, growth factors
  • AP - 1 complex subunit sigma - 2 is a protein that in humans is encoded by the AP 1 S 2 gene. Adaptor protein complex 1 is found at the cytoplasmic face of coated
  • AP - 3 complex subunit sigma - 1 is a protein that in humans is encoded by the AP 3 S 1 gene. GRCh38: Ensembl release 89: ENSG00000177879 - Ensembl, May 2017
  • AP - 4 complex subunit sigma - 1 is a protein that in humans is encoded by the AP 4 S 1 gene. The heterotetrameric adaptor protein AP complexes sort integral
  • complex 1 AP 1 B 1 AP 1 G 1 AP 1 G2 AP 1 M 1 AP 1 M2 AP1S1 AP 1 S 2 AP 1 S 3 complex 2 AP 2A 1 AP 2A2 AP 2B 1 AP 2M 1 AP 2 S 1 complex 3 AP 3B 1 AP 3B2 AP 3D 1 AP 3M 1 AP 3M2 AP 3 S 1 AP 3 S 2 complex
  • AP 4 is composed of 2 large chains, beta - 4 AP 4B 1 and epsilon - 4 AP 4E 1 this gene a medium chain, mu - 4 AP 4M 1 and a small chain, sigma - 4 AP 4 S 1
  • AP - 1 complex subunit beta - 1 is a protein that in humans is encoded by the AP 1 B 1 gene. Adaptor protein complex 1 is found at the cytoplasmic face of coated
  • AP 4 is composed of 2 large chains, beta - 4 AP 4B 1 this protein and epsilon - 4 AP 4E 1 a medium chain, mu - 4 AP 4M 1 and a small chain, sigma - 4 AP 4 S 1