ⓘ TOLLIP

                                     

ⓘ TOLLIP

It is an inhibitory adaptor protein within Toll-like receptors TLR. The TLR pathway is a part of the innate immune system that recognizes structurally conserved molecular patterns of microbial pathogens, leading to an inflammatory immune response.

                                     
  • and HMG2L1 proximally positioned. TOM1 has been shown to interact with TOLLIP and ZFYVE16. GRCh38: Ensembl release 89: ENSG00000100284 - Ensembl, May
  • shown to interact with: CHUK IKBKG IKK2, Myd88 NEMO SOCS1 STAT3 TRAF6 UBC, TOLLIP TLR4 IRAK1 signaling is involved in rheumatoid arthritis. GRCh38: Ensembl
  • membrane - bound and one soluble. IL1RAP has been shown to interact with TOLLIP and Interleukin 1 receptor, type I. GRCh38: Ensembl release 89: ENSG00000196083
  • Plumpton C Maschera B Lewis A Ray K Tschopp J Volpe F June 2000 Tollip a new component of the IL - 1RI pathway, links IRAK to the IL - 1 receptor
  • the toll - like receptor 2: TLR 2 has been shown to interact with TLR 1 and TOLLIP TLR2 resides on the plasma membrane where it responds to lipid - containing
  • domains recruit cytoplasmic adaptor proteins MyD88 UniProt Q99836 and TOLLIP Toll interacting protein, UniProt Q9H0E2 In turn, these associate with
  • Plumpton C, Maschera B, Lewis A, Ray K, Tschopp J, Volpe F Jun 2000 Tollip a new component of the IL - 1RI pathway, links IRAK to the IL - 1 receptor
  • Nakayama K 2006 Recruitment of clathrin onto endosomes by the Tom1 - Tollip complex Biochem. Biophys. Res. Commun. 341 1 143 9. doi: 10.1016 j.bbrc
  • 1038 ng1285. PMID 14702039. Katoh Y, Shiba Y, Mitsuhashi H, et al. 2004 Tollip and Tom1 form a complex and recruit ubiquitin - conjugated proteins onto early
  • SYT4 SYT5 SYT6 SYT7 SYT8 SYT9 SYTL1 SYTL2 SYTL3 SYTL4 SYTL5 TOLLIP UNC13A UNC13B UNC13C UNC13D WWC2 WWP1 WWP2 PTEN Walker EH, Pacold
  • Nigerians. He founded The Onofiok Luke Legislative Internship Programme TOLLIP in 2013. The programme is designed to train and mentor young Nigerians