ⓘ HAS2

                                     

ⓘ HAS2

Hyaluronan synthase 2 is an enzyme that in humans is encoded by the HAS2 gene.

Hyaluron or hyaluronic acid is an unbranched high molecular weight polysaccharide synthesized by a variety of organisms from bacteria to mammals and is a constituent of the extracellular matrix. It consists of alternating glucuronic acid and N-acetylglucosamine residues that are linked with beta-1-3 and beta-1-4 glycosidic bond. Hyaluronic acid is synthesized by membrane-bound synthase at the inner surface of the plasma membrane, and the chains are extruded via ABC-Transporter into the extracellular space. It offers a wide variety of functions, including space filling, lubrication of joints, and provision of a matrix through which cells can migrate. Hyaluronic acid is produced in the process of wound healing and tissue repair to provide a framework for ingrowth of blood vessels and fibroblasts. Changes in serum concentrations of hyaluronic acid are associated with inflammatory and degenerative arthropathy, such as rheumatoid arthritis. In addition, the interaction of hyaluronic acid with the receptor leukocyte CD44 is important in tissue-specific homing by leukocytes, and overexpression of hyaluronic acid receptors is correlated with tumor metastasis of tumors. HAS2 is a member of the vertebrate gene family encoding putative hyaluronan synthases, and amino acid sequence shows significant homology to glycosaminoglycan DG42 synthetase of clawed frogs and human and murine hyaluronan synthase 1.

                                     
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