ⓘ XRCC2

                                     

ⓘ XRCC2

This gene encodes a member of the RecA/Rad51-related protein family that participates in homologous recombination to maintain chromosome stability and repair DNA damage. This gene is involved in the repair of DNA double-strand breaks by homologous recombination and it functionally complements Chinese hamster irs1, a repair-deficient mutant that exhibits hypersensitivity to a number of different DNA-damaging agents.

In the XRCC2 protein is one of the five paralogs of human RAD51, including RAD51B RAD51L1, RAD51C RAD51L2, RAD51D RAD51L3, XRCC2 and XRCC3. They each share about 25% amino acid sequence identity with RAD51 and with each other.

In the RAD51 paralogs are all required for effective DNA double-strand breaks, break repair by homologous recombination and depletion of any search paralog in a significant reduction in the frequency of homologous recombination.

XRCC2 forms four parts, consisting of the three related paralogs: BCDX2 RAD51B-RAD51C-RAD51D-XRCC2 while two paralogs form a second complex CX3 RAD51C-XRCC3. These two complexes act at two different stages of stage of homologous DNA repair. In the BCDX2 complex is responsible for RAD51 recruitment or stabilization at sites of damage. In the BCDX2 complex appears to act by facilitating the Assembly and stability of RAD51 nucleoprotein filament.

In the CX3 complex acts below RAD51 recruitment to damage sites. In the CX3 complex was shown to bind to Holliday junction resolvase activity, probably in the role of a stabilizing transformation of gene pathways.

                                     
  • radiosensitivity. The XRCC 3 protein is one of five paralogs of RAD51, including RAD51B RAD51L1 RAD51C RAD51L 2 RAD51D RAD51L3 XRCC2 and XRCC 3. They each
  • repair protein XRCC 4 also known as X - ray repair cross - complementing protein 4 or XRCC 4 is a protein that in humans is encoded by the XRCC 4 gene. In addition
  • repair protein XRCC 1, also known as X - ray repair cross - complementing protein 1, is a protein that in humans is encoded by the XRCC 1 gene. XRCC 1 is involved
  • several other members of the RAD51 family, including RAD51L1, RAD51L 2 and XRCC2 The protein complex formed with this protein has been shown to catalyze
  • paralogs of RAD51, including RAD51B RAD51L1 RAD51C RAD51L 2 RAD51D RAD51L3 XRCC2 and XRCC 3. They each share about 25 amino acid sequence identity
  • Ku80 is a protein that, in humans, is encoded by the XRCC 5 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double - strand break
  • which further interacts with the other family members, such as RAD51, XRCC2 and XRCC 3. Overexpression of this gene was found to cause cell cycle G1 delay
  • Ku70 is a protein that, in humans, is encoded by the XRCC 6 gene. Together, Ku70 and Ku80 make up the Ku heterodimer, which binds to DNA double - strand break
  • Zhou ZQ, Walter CA, Albala JS, Busch DB, Thompson LH Sep 1997 The human XRCC 9 gene corrects chromosomal instability and mutagen sensitivities in CHO UV40