ⓘ PTPRN

                                     

ⓘ PTPRN

The protein encoded by this gene is a member of the protein tyrosine phosphatase PTP family and PTPRN subfamily. PTPs are known to be signaling molecules that regulate a variety of cellular processes including cell growth, differentiation, mitotic cycle, and oncogenic transformation. This PTP possesses an extracellular region, a single transmembrane region, and a single catalytic domain, and thus represents a receptor-type PTP. This PTP was found to be an autoantigen that is reactive with insulin-dependent diabetes mellitus IDDM patient sera, and thus may be a potential target of autoimmunity in diabetes mellitus.

                                     
  • ICAAR and phogrin is an enzyme that in humans is encoded by the PTPRN 2 gene. PTPRN and PTPRN 2 this gene are both found to be major autoantigens associated
  • PTPRB, PTPRC, PTPRD, PTPRE, PTPRF, PTPRG, PTPRH, PTPRJ, PTPRK, PTPRM, PTPRN PTPRN 2, PTPRO, PTPRQ, PTPRR, PTPRS, PTPRT, PTPRU, and PTPRZ. Ronald W. Dudek