ⓘ CRB1

                                     

ⓘ CRB1

Crumbs homolog 1 is a protein that in humans is encoded by the CRB1 gene.

This gene encodes a protein that is similar to the Drosophila crumbs protein and localizes to the inner segment of mammalian photoreceptors. In Drosophila, crumbs is localized to the stalk of the fly photoreceptor and may be a component of a molecular scaffold that controls proper development of polarity in the eye. Mutations in this gene are associated with severe form of pigmentary retinitis, RP12, and with congenital amaurosis Leber. Alternative spliced transcript variants have been observed but their full-length nature has yet to be determined. One small study shows that mutations in this gene are associated with keratoconus in patients that already have Lebers congenital amaurosis.

                                     
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  • clinically relevant behavior 1 CRB1 In - session occurrence of improvements is called clinically relevant behavior 2 CRB 2 The goal of FAP therapy is
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