ⓘ GCLM

                                     

ⓘ GCLM

Glutamate-cysteine ligase regulatory subunit is an enzyme that in humans is encoded by the GCLM gene.

Glutamate-cysteine ligase, also known as gamma-glutamylcysteine synthetase, the first rate limiting enzyme of glutathione synthesis. The enzyme consists of two subunits, a heavy catalytic subuit and a light regulatory subunit. Deficiency of gamma-glutamylcysteine synthetase, was implicated in some forms of hemolytic anemia.